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Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

Cellular senescence is a widespread stress response and is widely considered to be an alternative cancer therapeutic goal. Unlike apoptosis, senescence is composed of a diverse set of subphenotypes, depending on which of its associated effector programs are engaged. Here we establish a simple and se...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Sadaie, Mahito, Dillon, Christian, Narita, Masashi, Young, Andrew R. J., Cairney, Claire J., Godwin, Lauren S., Torrance, Christopher J., Bennett, Dorothy C., Keith, W. Nicol
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551313/
https://ncbi.nlm.nih.gov/pubmed/26133385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-01-0003
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