Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

BACKGROUND: Cellular senescence is a major barrier to tumour progression, though its role in pathogenesis of cancer and other diseases is poorly understood in vivo. Improved understanding of the degree to which latent senescence signalling persists in tumours might identify intervention strategies t...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lafferty-Whyte, Kyle, Bilsland, Alan, Cairney, Claire J, Hanley, Lorna, Jamieson, Nigel B, Zaffaroni, Nadia, Oien, Karin A, Burns, Sharon, Roffey, Jon, Boyd, Susan M, Keith, W Nicol
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2010
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091681/
https://ncbi.nlm.nih.gov/pubmed/20920304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-532
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