A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components. Chromatin immunoprecipitation combined with reporter-based transfection assays show that the C-terminal...

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Detalhes bibliográficos
Main Authors: Zhang, Xin, Neganova, Irina, Przyborski, Stefan, Yang, Chunbo, Cooke, Michael, Atkinson, Stuart P., Anyfantis, George, Fenyk, Stefan, Keith, W. Nicol, Hoare, Stacey F., Hughes, Owen, Strachan, Tom, Stojkovic, Miodrag, Hinds, Philip W., Armstrong, Lyle, Lako, Majlinda
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615089/
https://ncbi.nlm.nih.gov/pubmed/19139263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801009
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