Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

par Kamath, Amrita V., Iyer, Suhasini
Publié dans Pharm Res (2014)

Challenges and advances in the assessment of the disposition of antibody‐drug conjugates

par Kamath, Amrita V., Iyer, Suhasini
Publié dans Biopharm Drug Dispos (2015)

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

par Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita V., Crowell, Susan R.
Publié dans Front Pharmacol (2021)

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospi...

par Gupta, Priyanka, Kamath, Amrita V., Park, Summer, Chiu, Henry, Lutman, Jeff, Maia, Mauricio, Tan, Man-Wah, Xu, Min, Swem, Lee, Deng, Rong
Publié dans MAbs (2016)

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

par Zhou, Chenguang, Cai, Hao, Baruch, Amos, Lewin-Koh, Nicholas, Yang, Meng, Guo, Fengxun, Xu, Deming, Deng, Rong, Hazenbos, Wouter, Kamath, Amrita V.
Publié dans PLoS One (2019)

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

par Wang-Lin, Shun xin, Zhou, Chenguang, Kamath, Amrita V., Hong, Kyu, Koppada, Neelima, Saad, Ola M., Carrasco-Triguero, Montserrat, Khojasteh, Cyrus, Deng, Rong
Publié dans MAbs (2018)

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

par Deng, Rong, Zhou, Chenguang, Li, Dongwei, Cai, Hao, Sukumaran, Siddharth, Carrasco-Triguero, Montserrat, Saad, Ola, Nazzal, Denise, Lowe, Christopher, Ramanujan, Saroja, Kamath, Amrita V.
Publié dans MAbs (2019)

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

par Crowell, Susan R., Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M., Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V., Kelley, Robert F.
Publié dans Transl Vis Sci Technol (2019)

Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging

par Kamath, Amrita V., Williams, Simon P., Bullens, Sherry, Cowan, Kyra J., Stenberg, Yvonne, Cherry, Simon R., Rendig, Stephen, Kukis, David L., Griesemer, Chris, Damico-Beyer, Lisa A., Bunting, Stuart
Publié 2012

Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

par Zhou, Chenguang, Lehar, Sophie, Gutierrez, Johnny, Rosenberger, Carrie M., Ljumanovic, Nina, Dinoso, Jason, Koppada, Neelima, Hong, Kyu, Baruch, Amos, Carrasco-Triguero, Montserrat, Saad, Ola, Mariathasan, Sanjeev, Kamath, Amrita V.
Publié dans MAbs (2016)

Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an an...

par Figueroa, Isabel, Leipold, Doug, Leong, Steve, Zheng, Bing, Triguero-Carrasco, Montserrat, Fourie-O'Donohue, Aimee, Kozak, Katherine R., Xu, Keyang, Schutten, Melissa, Wang, Hong, Polson, Andrew G., Kamath, Amrita V.
Publié dans MAbs (2018)

A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibi...

par Peck, Melicent, Rothenberg, Michael E., Deng, Rong, Lewin-Koh, Nicholas, She, Gaohong, Kamath, Amrita V., Carrasco-Triguero, Montserrat, Saad, Ola, Castro, Aide, Teufel, Lisa, Dickerson, Daniel S., Leonardelli, Marisa, Tavel, Jorge A.
Publié dans Antimicrob Agents Chemother (2019)

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

par Bumbaca Yadav, Daniela, Reyes, Arthur E., Gupta, Priyanka, Vernes, Jean‐Michel, Meng, Y. Gloria, Schweiger, Michelle G., Stainton, Shannon L., Fuh, Germaine, Fielder, Paul J., Kamath, Amrita V., Shen, Ben‐Quan
Publié dans Pharmacol Res Perspect (2020)

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

par Kamath, Amrita V, Yip, Victor, Gupta, Priyanka, Boswell, C Andrew, Bumbaca, Daniela, Haughney, Peter, Castro, Joni, Tsai, Siao Ping, Pacheco, Glenn, Ross, Sarajane, Yan, Minhong, Damico-Beyer, Lisa A, Khawli, Leslie, Shen, Ben-Quan
Publié dans MAbs (2014)

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

par Li, Chunze, Zhang, Cindy, Deng, Rong, Leipold, Douglas, Li, Dongwei, Latifi, Brandon, Gao, Yuying, Zhang, Crystal, Li, Zao, Miles, Dale, Chen, Shang‐Chiung, Samineni, Divya, Wang, Bei, Agarwal, Priya, Lu, Dan, Prabhu, Saileta, Girish, Sandhya, Kamath, Amrita V.
Publié dans Clin Transl Sci (2019)

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

par Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, Spiess, Christoph, Kamath, Amrita V.
Publié dans MAbs (2018)

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia

par Leipold, Douglas D., Figueroa, Isabel, Masih, Shabkhaiz, Latifi, Brandon, Yip, Victor, Shen, Ben-Quan, Dere, Randall C., Carrasco-Triguero, Montserrat, Lee, M. Violet, Saad, Ola M., Liu, Luna, He, Jintang, Su, Dian, Xu, Keyang, Vuillemenot, Brian R., Laing, Steven T., Schutten, Melissa, Kozak, Katherine R., Zheng, Bing, Polson, Andrew G., Kamath, Amrita V.
Publié dans MAbs (2018)