Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice

DSTA4637A, a novel THIOMAB™ antibody antibiotic conjugate (TAC) against Staphylococcus aureus (S. aureus), is currently being investigated as a potential therapy against S. aureus infections. Structurally, TAC is composed of an anti-S. aureus antibody linked to a potent antibiotic, dmDNA31. The goal...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Zhou, Chenguang, Lehar, Sophie, Gutierrez, Johnny, Rosenberger, Carrie M., Ljumanovic, Nina, Dinoso, Jason, Koppada, Neelima, Hong, Kyu, Baruch, Amos, Carrasco-Triguero, Montserrat, Saad, Ola, Mariathasan, Sanjeev, Kamath, Amrita V.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098440/
https://ncbi.nlm.nih.gov/pubmed/27653831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1229722
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