Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

Staphylococcus aureus (S. aureus) infections are a leading cause of death by an infectious agent. Survival within host phagocytic cells is one mechanism by which S. aureus evades antibiotic treatment. A novel THIOMAB(™) antibody-antibiotic conjugate (TAC) strategy was developed to kill S. aureus int...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Zhou, Chenguang, Cai, Hao, Baruch, Amos, Lewin-Koh, Nicholas, Yang, Meng, Guo, Fengxun, Xu, Deming, Deng, Rong, Hazenbos, Wouter, Kamath, Amrita V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818770/
https://ncbi.nlm.nih.gov/pubmed/31661493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224096
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