Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

MHAA4549A is a human immunoglobulin G1 (IgG1) monoclonal antibody that binds to a highly conserved epitope on the stalk of influenza A hemagglutinin and blocks the hemagglutinin-mediated membrane fusion in the endosome, neutralizing all known human influenza A strains. Pharmacokinetics (PK) of MHAA4...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Gupta, Priyanka, Kamath, Amrita V., Park, Summer, Chiu, Henry, Lutman, Jeff, Maia, Mauricio, Tan, Man-Wah, Xu, Min, Swem, Lee, Deng, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037985/
https://ncbi.nlm.nih.gov/pubmed/27031797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1167294
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