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Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers

Hospitalized patients with severe influenza are at significant risk for morbidity and mortality. MHAA4549A is a human monoclonal immunoglobulin (Ig) G1 antibody that binds to a highly conserved stalk region of the influenza A virus hemagglutinin protein and neutralizes all tested seasonal human infl...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Lim, Jeremy J., Deng, Rong, Derby, Michael A., Larouche, Richard, Horn, Priscilla, Anderson, Malia, Maia, Mauricio, Carrier, Stephanie, Pelletier, Isabelle, Burgess, Tracy, Kulkarni, Priya, Newton, Elizabeth, Tavel, Jorge A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997859/
https://ncbi.nlm.nih.gov/pubmed/27381392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00607-16
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