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Challenges and advances in the assessment of the disposition of antibody‐drug conjugates

Antibody‐drug conjugates (ADCs) are a rapidly growing therapeutic platform for the treatment of cancer. ADCs consist of a cytotoxic small molecule drug linked to an antibody to provide targeted delivery of the cytotoxic agent to the tumor. Understanding the pharmacokinetics (PK) and pharmacodynamics...

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Bibliografski detalji
Izdano u:Biopharm Drug Dispos
Glavni autori: Kamath, Amrita V., Iyer, Suhasini
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032988/
https://ncbi.nlm.nih.gov/pubmed/25904406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1957
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