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Antibody-drug conjugates: recent advances in conjugation and linker chemistries

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. This new antibody-based molecular p...

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Bibliografske podrobnosti
izdano v:Protein Cell
Main Authors: Tsuchikama, Kyoji, An, Zhiqiang
Format: Artigo
Jezik:Inglês
Izdano: Higher Education Press 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777969/
https://ncbi.nlm.nih.gov/pubmed/27743348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0323-0
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