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Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates

Antibody-drug conjugates (ADCs) represent a new class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload. They were designed to allow specific targeting of highly potent cytotoxic agents to tumor cells whilst sparing normal cells. Frequent toxic...

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Bibliografske podrobnosti
izdano v:MAbs
Glavni avtor: Donaghy, Heather
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966843/
https://ncbi.nlm.nih.gov/pubmed/27045800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1156829
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