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Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

Antibody drug conjugates (ADCs) have emerged as an important pharmaceutical class of drugs designed to harness the specificity of antibodies with the potency of small molecule therapeutics. The three main components of ADCs are the antibody, the linker, and the payload; the majority of early work fo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:AAPS J
Prif Awduron: McCombs, Jessica R., Owen, Shawn C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365093/
https://ncbi.nlm.nih.gov/pubmed/25604608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9710-8
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