Chemical Modification of Linkers Provides Stable Linker–Payloads for the Generation of Antibody–Drug Conjugates

[Image: see text] Stability of antibody–drug conjugates (ADCs) in mouse serum is one of the critical requirements for the evaluation of ADCs in mouse tumor models. Described herein is a strategy to address the mouse serum instability of uncialamycin linker–payloads through various chemical approache...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Poudel, Yam B., Chowdari, Naidu S., Cheng, Heng, Iwuagwu, Christiana I., King, H. Dalton, Kotapati, Srikanth, Passmore, David, Rampulla, Richard, Mathur, Arvind, Vite, Gregory, Gangwar, Sanjeev
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667830/
https://ncbi.nlm.nih.gov/pubmed/33214828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00325
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