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Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice
Valine–citrulline linkers are commonly used as enzymatically cleavable linkers for antibody–drug conjugates. While stable in human plasma, these linkers are unstable in mouse plasma due to susceptibility to an extracellular carboxylesterase. This instability often triggers premature release of drugs...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6023893/ https://ncbi.nlm.nih.gov/pubmed/29955061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04982-3 |
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