Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice

Valine–citrulline linkers are commonly used as enzymatically cleavable linkers for antibody–drug conjugates. While stable in human plasma, these linkers are unstable in mouse plasma due to susceptibility to an extracellular carboxylesterase. This instability often triggers premature release of drugs...

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Udgivet i:Nat Commun
Main Authors: Anami, Yasuaki, Yamazaki, Chisato M., Xiong, Wei, Gui, Xun, Zhang, Ningyan, An, Zhiqiang, Tsuchikama, Kyoji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023893/
https://ncbi.nlm.nih.gov/pubmed/29955061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04982-3
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