Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients

The rapid advancement in the development of therapeutic proteins, including monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs), has created a novel mechanism to selectively deliver highly potent cytotoxic agents in the treatment of cancer. These agents provide numerous benefits compare...

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Bibliographic Details
Published in:Antibodies (Basel)
Main Authors: Lucas, Andrew T., Robinson, Ryan, Schorzman, Allison N., Piscitelli, Joseph A., Razo, Juan F., Zamboni, William C.
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640706/
https://ncbi.nlm.nih.gov/pubmed/31544809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8010003
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