The enzyme aromatic amine dehydrogenase induces a substrate conformation crucial for promoting vibration that significantly reduces the effective potential energy barrier to proton...

Por Johannissen, Linus O., Scrutton, Nigel S., Sutcliffe, Michael J.
Publicado em 2008

Barrier Compression and Its Contribution to Both Classical and Quantum Mechanical Aspects of Enzyme Catalysis

Por Hay, Sam, Johannissen, Linus O., Sutcliffe, Michael J., Scrutton, Nigel S.
Publicado em 2010

Coupled Motions Direct Electrons along Human Microsomal P450 Chains

Por Pudney, Christopher R., Khara, Basile, Johannissen, Linus O., Scrutton, Nigel S.
Publicado em 2011

Vertebrate Cryptochromes are Vestigial Flavoproteins

Por Kutta, Roger J., Archipowa, Nataliya, Johannissen, Linus O., Jones, Alex R., Scrutton, Nigel S.
Publicado no Sci Rep (2017)

C3 and C6 Modification‐Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones

Por Issa, Issa S., Toogood, Helen S., Johannissen, Linus O., Raftery, James, Scrutton, Nigel S., Gardiner, John M.
Publicado no Chemistry (2019)

Identification of B cell epitopes enhanced by protein unfolding and aggregation

Por Eyes, Timothy J., Austerberry, James I., Dearman, Rebecca J., Johannissen, Linus O., Kimber, Ian, Smith, Noel, Thistlethwaite, Angela, Derrick, Jeremy P.
Publicado no Mol Immunol (2019)

Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches

Por Jeffreys, Laura N., Pacholarz, Kamila J., Johannissen, Linus O., Girvan, Hazel M., Barran, Perdita E., Voice, Michael W., Munro, Andrew W.
Publicado no J Biol Chem (2020)

Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction

Por Crawshaw, Rebecca, Crossley, Amy E., Johannissen, Linus, Burke, Ashleigh J., Hay, Sam, Levy, Colin, Baker, David, Lovelock, Sarah L., Green, Anthony P.
Publicado no Nat Chem (2022)

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

Por Longbotham, James E., Levy, Colin, Johannissen, Linus O., Tarhonskaya, Hanna, Jiang, Shuo, Loenarz, Christoph, Flashman, Emily, Hay, Sam, Schofield, Christopher J., Scrutton, Nigel S.
Publicado no Biochemistry (2015)

Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems

Por Sutcliffe, Michael J, Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O, Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E, Mulholland, Adrian J, Leys, David, Scrutton, Nigel S
Publicado em 2006

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification

Por Payne, Karl A. P., Fisher, Karl, Sjuts, Hanno, Dunstan, Mark S., Bellina, Bruno, Johannissen, Linus, Barran, Perdita, Hay, Sam, Rigby, Stephen E. J., Leys, David
Publicado no J Biol Chem (2015)

Native mass spectrometry reveals the conformational diversity of the UVR8 photoreceptor

Por Camacho, Inês S., Theisen, Alina, Johannissen, Linus O., Díaz-Ramos, L. Aranzazú, Christie, John M., Jenkins, Gareth I., Bellina, Bruno, Barran, Perdita, Jones, Alex R.
Publicado no Proc Natl Acad Sci U S A (2019)

Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation

Por Leferink, Nicole G. H., Ranaghan, Kara E., Battye, Jaime, Johannissen, Linus O., Hay, Sam, van der Kamp, Marc W., Mulholland, Adrian J., Scrutton, Nigel S.
Publicado no Chembiochem (2019)

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

Por Czarnota, Sylwia, Johannissen, Linus O., Baxter, Nicola J., Rummel, Felix, Wilson, Alex L., Cliff, Matthew J., Levy, Colin W., Scrutton, Nigel S., Waltho, Jonathan P., Hay, Sam
Publicado no ACS Catal (2019)

The photochemical mechanism of a B(12)-dependent photoreceptor protein

Por Kutta, Roger J., Hardman, Samantha J. O., Johannissen, Linus O., Bellina, Bruno, Messiha, Hanan L., Ortiz-Guerrero, Juan Manuel, Elías-Arnanz, Montserrat, Padmanabhan, S., Barran, Perdita, Scrutton, Nigel S., Jones, Alex R.
Publicado no Nat Commun (2015)

Engineering the “Missing Link” in Biosynthetic (−)-Menthol Production: Bacterial Isopulegone Isomerase

Por Currin, Andrew, Dunstan, Mark S., Johannissen, Linus O., Hollywood, Katherine A., Vinaixa, Maria, Jervis, Adrian J., Swainston, Neil, Rattray, Nicholas J. W., Gardiner, John M., Kell, Douglas B., Takano, Eriko, Toogood, Helen S., Scrutton, Nigel S.
Publicado no ACS Catal (2018)

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase

Por Karuppiah, Vijaykumar, Ranaghan, Kara E., Leferink, Nicole G. H., Johannissen, Linus O., Shanmugam, Muralidharan, Ní Cheallaigh, Aisling, Bennett, Nathan J., Kearsey, Lewis J., Takano, Eriko, Gardiner, John M., van der Kamp, Marc W., Hay, Sam, Mulholland, Adrian J., Leys, David, Scrutton, Nigel S.
Publicado no ACS Catal (2017)