Identification of B cell epitopes enhanced by protein unfolding and aggregation

Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate...

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Udgivet i:Mol Immunol
Main Authors: Eyes, Timothy J., Austerberry, James I., Dearman, Rebecca J., Johannissen, Linus O., Kimber, Ian, Smith, Noel, Thistlethwaite, Angela, Derrick, Jeremy P.
Format: Artigo
Sprog:Inglês
Udgivet: Pergamon Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344229/
https://ncbi.nlm.nih.gov/pubmed/30550980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2018.11.020
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