Editor’s Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response

Protein aggregation is associated with enhanced immunogenicity of biotherapeutics. As a result, regulatory guidelines recommend screening for aggregation during bioprocessing. However, the mechanisms underlying the enhanced immunogenicity of aggregates are poorly understood. In the investigations de...

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Udgivet i:Toxicol Sci
Main Authors: Ratanji, Kirsty D., Dearman, Rebecca J., Kimber, Ian, Thorpe, Robin, Wadhwa, Meenu, Derrick, Jeremy P.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
T Helper 1-Type Response Induced by Subvisible Aggregates of Immunogenic Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036615/
https://ncbi.nlm.nih.gov/pubmed/27370416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw121
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