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Immunogenicity of therapeutic proteins: Influence of aggregation
The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Informa Healthcare USA, Inc.
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002659/ https://ncbi.nlm.nih.gov/pubmed/23919460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/1547691X.2013.821564 |
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