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Editor’s Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response
Protein aggregation is associated with enhanced immunogenicity of biotherapeutics. As a result, regulatory guidelines recommend screening for aggregation during bioprocessing. However, the mechanisms underlying the enhanced immunogenicity of aggregates are poorly understood. In the investigations de...
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| Izdano u: | Toxicol Sci |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036615/ https://ncbi.nlm.nih.gov/pubmed/27370416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw121 |
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