HIV drug nucleoside reverse transcriptase inhibitors as promising anti-inflammation therapeutics by targeting P2X7-dependent large pore formation: one stone for two birds?

Por Jiang, Lin-Hua
Publicado no Front Pharmacol (2015)

Requirement for the N-Terminal Coiled-Coil Domain for Expression and Function, but not Subunit Interaction of, the ADPR-Activated TRPM2 Channel

Por Mei, Zhu-Zhong, Jiang, Lin-Hua
Publicado em 2009

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function

Por Mei, Zhu-Zhong, Mao, Hong-Ju, Jiang, Lin-Hua
Publicado em 2006

New structure enlivens interest in P2X receptors

Por Browne, Liam E., Jiang, Lin-Hua, North, R. Alan
Publicado em 2010

ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know?

Por Wei, Linyu, Caseley, Emily, Li, Dongliang, Jiang, Lin-Hua
Publicado no Front Pharmacol (2016)

Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies

Por Caseley, Emily A, Muench, Stephen P, Jiang, Lin-Hua
Publicado no Purinergic Signal (2016)

Kinetics of antagonist actions at rat P2X(2/3) heteromeric receptors

Por Spelta, Valeria, Jiang, Lin-Hua, Surprenant, Annmarie, North, R Alan
Publicado em 2002

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2

Por Mei, Zhu-Zhong, Xia, Rong, Beech, David J, Jiang, Lin-Hua
Publicado em 2006

Pharmacological properties of the rhesus macaque monkey P2X7 receptor

Por Bradley, Helen J, Browne, Liam E, Yang, Wei, Jiang, Lin-Hua
Publicado em 2011

Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphis...

Por Jiang, Lin-Hua, Baldwin, Jocelyn M., Roger, Sebastien, Baldwin, Stephen A.
Publicado em 2013

TRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune Cells

Por Syed Mortadza, Sharifah Alawieyah, Wang, Lu, Li, Dongliang, Jiang, Lin-Hua
Publicado no Front Immunol (2015)

Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells

Por Mortadza, Sharifah Syed, Sim, Joan A., Stacey, Martin, Jiang, Lin-Hua
Publicado no Sci Rep (2017)

Role of the domain encompassing Arg(304)–Ile(328) in rat P2X(2) receptor conformation revealed by alterations in complex glycosylation at Asn(298)

Por Young, Mark T., Zhang, Yi-Hong, Cao, Lishuang, Broomhead, Helen, Jiang, Lin-Hua
Publicado em 2008

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists

Por Caseley, Emily A., Muench, Stephen P., Fishwick, Colin W., Jiang, Lin-Hua
Publicado no Biochem Pharmacol (2016)

Proteomic and functional evidence for a P2X(7) receptor signalling complex

Por Kim, Miran, Jiang, Lin-Hua, Wilson, Heather L., North, R.Alan, Surprenant, Annmarie
Publicado em 2001

Interaction between cysteines introduced into each transmembrane domain of the rat P2X(2) receptor

Por Spelta, Valeria, Jiang, Lin-Hua, Bailey, R Jayne, Surprenant, Annmarie, North, R Alan
Publicado em 2003

Inactivation of TRPM2 Channels by Extracellular Divalent Copper

Por Yu, Wenyue, Jiang, Lin-Hua, Zheng, Yang, Hu, Xupang, Luo, Jianhong, Yang, Wei
Publicado no PLoS One (2014)

Zinc Inactivates Melastatin Transient Receptor Potential 2 Channels via the Outer Pore

Por Yang, Wei, Manna, Paul T., Zou, Jie, Luo, Jianhong, Beech, David J., Sivaprasadarao, Asipu, Jiang, Lin-Hua
Publicado em 2011

Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers

Por Caseley, Emily A., Muench, Stephen P., Roger, Sebastien, Mao, Hong-Ju, Baldwin, Stephen A., Jiang, Lin-Hua
Publicado em 2014

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human

Por Caseley, Emily A., Muench, Stephen P., Baldwin, Stephen A., Simmons, Katie, Fishwick, Colin W., Jiang, Lin-Hua
Publicado no Bioorg Med Chem Lett (2015)