Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells

Excessive Zn(2+) causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H(2)O(2)/Zn(2+)-induced Ca(2+) signalling and cell death in microglial cells. H(2)O(2)/Zn(2+) induced concentration-dependent increases in cytosolic Ca(2+) concentration...

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Foilsithe in:Sci Rep
Main Authors: Mortadza, Sharifah Syed, Sim, Joan A., Stacey, Martin, Jiang, Lin-Hua
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359577/
https://ncbi.nlm.nih.gov/pubmed/28322340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45032
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