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Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells
Excessive Zn(2+) causes brain damage via promoting ROS generation. Here we investigated the role of ROS-sensitive TRPM2 channel in H(2)O(2)/Zn(2+)-induced Ca(2+) signalling and cell death in microglial cells. H(2)O(2)/Zn(2+) induced concentration-dependent increases in cytosolic Ca(2+) concentration...
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| Yayımlandı: | Sci Rep |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5359577/ https://ncbi.nlm.nih.gov/pubmed/28322340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45032 |
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