TLR-induced activation of Btk – Role for endosomal MHC class II molecules revealed

Por Ní Gabhann, Joan, Jefferies, Caroline A
Publicado em 2011

Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity

Por Stacey, Kevin B., Breen, Eamon, Jefferies, Caroline A.
Publicado em 2012

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

Por Lazzari, Elisa, Korczeniewska, Justyna, Ní Gabhann, Joan, Smith, Siobhán, Barnes, Betsy J., Jefferies, Caroline A.
Publicado em 2014

THE E3 UBIQUITIN LIGASE RO52 NEGATIVELY REGULATES IFN-β PRODUCTION POST-PATHOGEN RECOGNITION BY POLYUBIQUITIN-MEDIATED DEGRADATION OF IRF3

Por Higgs, Rowan, Gabhann, Joan Ní, Larbi, Nadia Ben, Breen, Eamon P., Fitzgerald, Katherine A., Jefferies, Caroline A.
Publicado em 2008

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

Por Higgs, Rowan, Lazzari, Elisa, Wynne, Claire, Ní Gabhann, Joan, Espinosa, Alexander, Wahren-Herlenius, Marie, Jefferies, Caroline A.
Publicado em 2010

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.

Por Gray, Pearl, Dunne, Aisling, Brikos, Constantinos, Jefferies, Caroline A., Doyle, Sarah L., O′Neill, Luke A. J.
Publicado no J Biol Chem (2016)

Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

Por Byrne, Jennifer C., Ní Gabhann, Joan, Lazzari, Elisa, Mahony, Rebecca, Smith, Siobhán, Stacey, Kevin, Wynne, Claire, Jefferies, Caroline A.
Publicado em 2012

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide

Por Ní Gabhann, Joan, Hams, Emily, Smith, Siobhán, Wynne, Claire, Byrne, Jennifer C., Brennan, Kiva, Spence, Shaun, Kissenpfennig, Adrien, Johnston, James A., Fallon, Padraic G., Jefferies, Caroline A.
Publicado em 2014

TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

Por Wynne, Claire, Lazzari, Elisa, Smith, Siobhán, McCarthy, Eoghan M., Ní Gabhann, Joan, Kallal, Lara E., Higgs, Rowan, Cryan, Sally Ann, Biron, Christine A., Jefferies, Caroline A.
Publicado em 2014

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

Por Meehan, Maria, Parthasarathi, Laavanya, Moran, Niamh, Jefferies, Caroline A, Foley, Niamh, Lazzari, Elisa, Murphy, Derek, Ryan, Jacqueline, Ortiz, Berenice, M Fabius, Armida W, Chan, Timothy A, Stallings, Raymond L
Publicado em 2012

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

Por Espinosa, Alexander, Dardalhon, Valerie, Brauner, Susanna, Ambrosi, Aurelie, Higgs, Rowan, Quintana, Fransisco J., Sjöstrand, Maria, Eloranta, Maija-Leena, Ní Gabhann, Joan, Winqvist, Ola, Sundelin, Birgitta, Jefferies, Caroline A., Rozell, Björn, Kuchroo, Vijay K., Wahren-Herlenius, Marie
Publicado em 2009