Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

Ro52/Trim21 is targeted as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome. Polymorphisms in the Ro52 gene have been linked to these autoimmune conditions, but the molecular mechanism by which Ro52 may promote development of systemic autoimmune diseases has not been explor...

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Hlavní autoři: Espinosa, Alexander, Dardalhon, Valerie, Brauner, Susanna, Ambrosi, Aurelie, Higgs, Rowan, Quintana, Fransisco J., Sjöstrand, Maria, Eloranta, Maija-Leena, Ní Gabhann, Joan, Winqvist, Ola, Sundelin, Birgitta, Jefferies, Caroline A., Rozell, Björn, Kuchroo, Vijay K., Wahren-Herlenius, Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722164/
https://ncbi.nlm.nih.gov/pubmed/19635858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090585
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