Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren's syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3/...

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Autori principali: Higgs, Rowan, Lazzari, Elisa, Wynne, Claire, Ní Gabhann, Joan, Espinosa, Alexander, Wahren-Herlenius, Marie, Jefferies, Caroline A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909902/
https://ncbi.nlm.nih.gov/pubmed/20668674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011776
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