TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune response. In this study we identify TRIM68, a...

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Detalhes bibliográficos
Main Authors: Wynne, Claire, Lazzari, Elisa, Smith, Siobhán, McCarthy, Eoghan M., Ní Gabhann, Joan, Kallal, Lara E., Higgs, Rowan, Cryan, Sally Ann, Biron, Christine A., Jefferies, Caroline A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084880/
https://ncbi.nlm.nih.gov/pubmed/24999993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101503
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