Angiogenesis as a therapeutic target in cancer

Por Kumaran, Gireesh, Clamp, Andrew R, Jayson, Gordon C
Publicado no Clin Med (Lond) (2008)

Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by Heparin-binding Epidermal Growth Factor (EGF)-like Growth Factor/EGF Receptor Si...

Por Cole, Claire L., Rushton, Graham, Jayson, Gordon C., Avizienyte, Egle
Publicado em 2014

Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications

Por Baráth, Marek, Hansen, Steen U., Dalton, Charlotte E., Jayson, Gordon C., Miller, Gavin J., Gardiner, John M.
Publicado no Molecules (2015)

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

Por Miller, Gavin J., Broberg, Karl. R., Rudd, Claire, Helliwell, Madeleine R., Jayson, Gordon C., Gardiner, John M.
Publicado no Org Biomol Chem (2015)

Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.

Por Blackhall, Fiona H, Merry, Catherine L R, Lyon, Malcolm, Jayson, Gordon C, Folkman, Judah, Javaherian, Kashi, Gallagher, John T
Publicado em 2003

Synthetic Heparan Sulfate Oligosaccharides Inhibit Endothelial Cell Functions Essential for Angiogenesis

Por Cole, Claire L., Hansen, Steen U., Baráth, Marek, Rushton, Graham, Gardiner, John M., Avizienyte, Egle, Jayson, Gordon C.
Publicado em 2010

Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies

Por Hansen, Steen U., Miller, Gavin J., Cole, Claire, Rushton, Graham, Avizienyte, Egle, Jayson, Gordon C., Gardiner, John M.
Publicado em 2013

Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy

Por Miller, Gavin J., Hansen, Steen U., Baráth, Marek, Johannessen, Christian, Blanch, Ewan W., Jayson, Gordon C., Gardiner, John M.
Publicado no Carbohydr Res (2014)

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

Por Jayson, Gordon C., Hansen, Steen U., Miller, Gavin J., Cole, Claire L., Rushton, Graham, Avizienyte, Egle, Gardiner, John M.
Publicado no Chem Commun (Camb) (2015)

Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo

Por Avizienyte, Egle, Cole, Claire L., Rushton, Graham, Miller, Gavin J., Bugatti, Antonella, Presta, Marco, Gardiner, John M., Jayson, Gordon C.
Publicado no PLoS One (2016)

Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer

Por Cole, Claire, Lau, Sin, Backen, Alison, Clamp, Andrew, Rushton, Graham, Dive, Caroline, Hodgkinson, Cassandra, McVey, Rhona, Kitchener, Henry, Jayson, Gordon C
Publicado em 2010

Inhibition of carboplatin-induced DNA interstrand crosslink repair by gemcitabine in patients receiving these drugs for ‘platinum-resistant’ ovarian cancer

Por Ledermann, Jonathan A, Gabra, Hani, Jayson, Gordon C, Spanswick, Victoria J, Rustin, Gordon JS, Jitlal, Mark, James, Lindsay E, Hartley, John A
Publicado no Clin Cancer Res (2010)

Endothelial Heparan Sulfate 6-O-Sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor

Por Ferreras, Cristina, Rushton, Graham, Cole, Claire L., Babur, Muhammad, Telfer, Brian A., van Kuppevelt, Toin H., Gardiner, John M., Williams, Kaye J., Jayson, Gordon C., Avizienyte, Egle
Publicado em 2012

The combination of circulating Ang1 and Tie2 levels predict progression free survival advantage in Bevacizumab-treated ovarian cancer patients

Por Backen, Alison, Renehan, Andrew G., Clamp, Andrew R., Berzuini, Carlo, Zhou, Cong, Oza, Amit, Bannoo, Selina, Scherer, Stefan J., Banks, Rosamonde E., Dive, Caroline, Jayson, Gordon C.
Publicado em 2014

Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab

Por Zhou, Cong, Clamp, Andrew, Backen, Alison, Berzuini, Carlo, Renehan, Andrew, Banks, Rosamonde E, Kaplan, Richard, Scherer, Stefan J, Kristensen, Gunnar B, Pujade-Lauraine, Eric, Dive, Caroline, Jayson, Gordon C
Publicado no Br J Cancer (2016)

Predicting response to bevacizumab in ovarian cancer: a panel of potential biomarkers informing treatment selection

Por Collinson, Fiona, Hutchinson, Michelle, Craven, Rachel A., Cairns, David A., Zougman, Alexandre, Wind, Tobias C., Gahir, Narinder, Messenger, Michael P., Jackson, Sharon, Thompson, Douglas, Adusei, Cybil, Ledermann, Jonathan, Hall, Geoffrey, Jayson, Gordon C., Selby, Peter J., Banks, Rosamonde E.
Publicado em 2013

Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial

Por Oza, Amit M, Cook, Adrian D, Pfisterer, Jacobus, Embleton, Andrew, Ledermann, Jonathan A, Pujade-Lauraine, Eric, Kristensen, Gunnar, Carey, Mark S, Beale, Philip, Cervantes, Andrés, Park-Simon, Tjoung-Won, Rustin, Gordon, Joly, Florence, Mirza, Mansoor R, Plante, Marie, Quinn, Michael, Poveda, Andrés, Jayson, Gordon C, Stark, Dan, Swart, Ann Marie, Farrelly, Laura, Kaplan, Richard, Parmar, Mahesh K B, Perren, Timothy J
Publicado no Lancet Oncol (2015)

Quantifying anti-vascular effects of monoclonal antibodies to VEGF: insights from multi-modality cross species imaging in colorectal cancer

Por O’Connor, James P B, Carano, Richard A D, Clamp, Andrew R, Ross, Jed, Ho, Calvin C K, Jackson, Alan, Parker, Geoff J M, Rose, Chris J, Peale, Franklin V, Friesenhahn, Michel, Mitchell, Claire L, Watson, Yvonne, Roberts, Caleb, Hope, Lynn, Cheung, Sue, Reslan, Hani Bou, Go, Mary Ann T, Pacheco, Glenn J, Wu, Xiumin, Cao, Tim C, Ross, Sarajane, Buonaccorsi, Giovanni A, Davies, Karen, Hasan, Jurjees, Thornton, Paula, del Puerto, Olivia, Ferrara, Napoleone, van Bruggen, Nicholas, Jayson, Gordon C
Publicado no Clin Cancer Res (2009)

Molecular phenotyping of a UK population: defining the human serum metabolome

Por Dunn, Warwick B., Lin, Wanchang, Broadhurst, David, Begley, Paul, Brown, Marie, Zelena, Eva, Vaughan, Andrew A., Halsall, Antony, Harding, Nadine, Knowles, Joshua D., Francis-McIntyre, Sue, Tseng, Andy, Ellis, David I., O’Hagan, Steve, Aarons, Gill, Benjamin, Boben, Chew-Graham, Stephen, Moseley, Carly, Potter, Paula, Winder, Catherine L., Potts, Catherine, Thornton, Paula, McWhirter, Catriona, Zubair, Mohammed, Pan, Martin, Burns, Alistair, Cruickshank, J. Kennedy, Jayson, Gordon C., Purandare, Nitin, Wu, Frederick C. W., Finn, Joe D., Haselden, John N., Nicholls, Andrew W., Wilson, Ian D., Goodacre, Royston, Kell, Douglas B.
Publicado no Metabolomics (2014)

Imaging biomarker roadmap for cancer studies

Por O’Connor, James P. B., Aboagye, Eric O., Adams, Judith E., Aerts, Hugo J. W. L., Barrington, Sally F., Beer, Ambros J., Boellaard, Ronald, Bohndiek, Sarah E., Brady, Michael, Brown, Gina, Buckley, David L., Chenevert, Thomas L., Clarke, Laurence P., Collette, Sandra, Cook, Gary J., deSouza, Nandita M., Dickson, John C., Dive, Caroline, Evelhoch, Jeffrey L., Faivre-Finn, Corinne, Gallagher, Ferdia A., Gilbert, Fiona J., Gillies, Robert J., Goh, Vicky, Griffiths, John R., Groves, Ashley M., Halligan, Steve, Harris, Adrian L., Hawkes, David J., Hoekstra, Otto S., Huang, Erich P., Hutton, Brian F., Jackson, Edward F., Jayson, Gordon C., Jones, Andrew, Koh, Dow-Mu, Lacombe, Denis, Lambin, Philippe, Lassau, Nathalie, Leach, Martin O., Lee, Ting-Yim, Leen, Edward L., Lewis, Jason S., Liu, Yan, Lythgoe, Mark F., Manoharan, Prakash, Maxwell, Ross J., Miles, Kenneth A., Morgan, Bruno, Morris, Steve, Ng, Tony, Padhani, Anwar R., Parker, Geoff J. M., Partridge, Mike, Pathak, Arvind P., Peet, Andrew C., Punwani, Shonit, Reynolds, Andrew R., Robinson, Simon P., Shankar, Lalitha K., Sharma, Ricky A., Soloviev, Dmitry, Stroobants, Sigrid, Sullivan, Daniel C., Taylor, Stuart A., Tofts, Paul S., Tozer, Gillian M., van Herk, Marcel, Walker-Samuel, Simon, Wason, James, Williams, Kaye J., Workman, Paul, Yankeelov, Thomas E., Brindle, Kevin M., McShane, Lisa M., Jackson, Alan, Waterton, John C.
Publicado no Nat Rev Clin Oncol (2016)