Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo

Heparan sulphate (HS), a ubiquitously expressed glycosaminoglycan (GAG), regulates multiple cellular functions by mediating interactions between numerous growth factors and their cell surface cognate receptors. However, the structural specificity of HS in these interactions remains largely undefined...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Avizienyte, Egle, Cole, Claire L., Rushton, Graham, Miller, Gavin J., Bugatti, Antonella, Presta, Marco, Gardiner, John M., Jayson, Gordon C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973927/
https://ncbi.nlm.nih.gov/pubmed/27490176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159739
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