Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo

Heparan sulphate (HS), a ubiquitously expressed glycosaminoglycan (GAG), regulates multiple cellular functions by mediating interactions between numerous growth factors and their cell surface cognate receptors. However, the structural specificity of HS in these interactions remains largely undefined...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Avizienyte, Egle, Cole, Claire L., Rushton, Graham, Miller, Gavin J., Bugatti, Antonella, Presta, Marco, Gardiner, John M., Jayson, Gordon C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973927/
https://ncbi.nlm.nih.gov/pubmed/27490176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159739
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