Endothelial Heparan Sulfate 6-O-Sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor

Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor 165 (VEGF(165)) are potent pro-angiogenic growth factors that play a pivotal role in tumor angiogenesis. The activity of these growth factors is regulated by heparan sulfate (HS), which is essential for the formation of FGF2/FG...

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Detalhes bibliográficos
Main Authors: Ferreras, Cristina, Rushton, Graham, Cole, Claire L., Babur, Muhammad, Telfer, Brian A., van Kuppevelt, Toin H., Gardiner, John M., Williams, Kaye J., Jayson, Gordon C., Avizienyte, Egle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476281/
https://ncbi.nlm.nih.gov/pubmed/22927437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384875
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