An Inducible Heat Shock Protein 70 Small Molecule Inhibitor Demonstrates Anti-Dengue Virus Activity, Validating Hsp70 as a Host Antiviral Target

Por Howe, Matthew K., Speer, Brittany L., Hughes, Philip F., Loiselle, David R., Vasudevan, Subhash, Haystead, Timothy A. J.
Publicado no Antiviral Res (2016)

A Highly Selective Hsp90 Affinity Chromatography Resin with a Cleavable Linker

Por Hughes, Philip F, Barrott, Jared J, Carlson, David A, Loiselle, David R, Speer, Brittany L, Bodoor, Khaldon, Rund, Lauretta A, Haystead, Timothy A J
Publicado em 2012

Tethered Hsp90 Inhibitors Carrying Optical or Radioiodinated Probes Reveal Selective Internalization of Ectopic Hsp90 in Malignant Breast Tumor Cells

Por Barrott, Jared J., Hughes, Philip F., Osada, Takuya, Yang, Xiao-Yi, Hartman, Zachary C., Loiselle, David R., Spector, Neil L., Neckers, Len, Rajaram, Narasimhan, Hu, Fangyao, Ramanujam, Nimmi, Vaidyanathan, Ganesan, Zalutsky, Michael R., Lyerly, H. Kim, Haystead, Timothy A.
Publicado em 2013

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Por Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi
Publicado no Nat Commun (2016)

Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF(α) inhibition for cancer and autoimmune disease

Por Totzke, Juliane, Gurbani, Deepak, Raphemot, Rene, Hughes, Philip F., Bodoor, Khaldon, Carlson, David A., Loiselle, David R., Bera, Asim K., Eibschutz, Liesl S., Perkins, Marisha M., Eubanks, Amber L., Campbell, Phillip L., Fox, David A., Westover, Kenneth D., Haystead, Timothy A. J., Derbyshire, Emily R.
Publicado no Cell Chem Biol (2017)

Identification of an Allosteric Small Molecule Inhibitor Selective for Inducible Form of Heat Shock Protein 70

Por Howe, Matthew K., Bodoor, Khaldon, Carlson, David A., Hughes, Philip F., Alwarawrah, Yazan, Loiselle, David R., Jaeger, Alex M., Darr, David B., Jordan, Jamie L., Hunter, Lucas M., Molzberger, Eileen T., Gobillot, Theodore A., Thiele, Dennis J., Brodsky, Jeffrey L., Spector, Neil L., Haystead, Timothy A. J.
Publicado no Chem Biol (2014)

Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor

Por Carlson, David A., Franke, Aaron S., Weitzel, Douglas H., Speer, Brittany L., Hughes, Philip F., Hagerty, Laura, Fortner, Christopher N., Veal, James M., Barta, Thomas E., Zieba, Bartosz J., Somlyo, Avril V., Sutherland, Cindy, Deng, Jing Ti, Walsh, Michael P., MacDonald, Justin A., Haystead, Timothy A. J.
Publicado no ACS Chem Biol (2013)