Tethered Hsp90 Inhibitors Carrying Optical or Radioiodinated Probes Reveal Selective Internalization of Ectopic Hsp90 in Malignant Breast Tumor Cells

SUMMARY: Hsp90 inhibitors have demonstrated unusual selectivity for tumor cells despite its ubiquitous expression. This phenomenon has remained unexplained but could be influenced by ectopically expressed Hsp90 in tumors. We have synthesized novel Hsp90 inhibitors that can carry optical or radioiodi...

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Detalhes bibliográficos
Main Authors: Barrott, Jared J., Hughes, Philip F., Osada, Takuya, Yang, Xiao-Yi, Hartman, Zachary C., Loiselle, David R., Spector, Neil L., Neckers, Len, Rajaram, Narasimhan, Hu, Fangyao, Ramanujam, Nimmi, Vaidyanathan, Ganesan, Zalutsky, Michael R., Lyerly, H. Kim, Haystead, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815696/
https://ncbi.nlm.nih.gov/pubmed/24035283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.08.004
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