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The complex dance of the molecular chaperone Hsp90

Hsp90 chaperone function requires traversal of a nucleotide-dependent conformational cycle, but the slow and variable rate of Hsp90-mediated ATP hydrolysis is difficult to envision as a determinant of conformational change. A recent study solves this dilemma by showing that Hsp90 samples multiple co...

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Bibliografiske detaljer
Udgivet i:Trends Biochem Sci
Main Authors: Neckers, Len, Mollapour, Mehdi, Tsutsumi, Shinji
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282695/
https://ncbi.nlm.nih.gov/pubmed/19359180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2009.01.006
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