The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show...

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Publicado no:Nat Commun
Main Authors: Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931344/
https://ncbi.nlm.nih.gov/pubmed/27353360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12037
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