Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this process occurs abruptly or gradually in the cellular context....

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Bibliographic Details
Published in:Cell Rep
Main Authors: Sager, Rebecca A., Woodford, Mark R., Backe, Sarah J., Makedon, Alan M., Baker-Williams, Alexander J., DiGregorio, Bryanna T., Loiselle, David R., Haystead, Timothy A., Zachara, Natasha E., Prodromou, Chrisostomos, Bourboulia, Dimitra, Schmidt, Laura S., Linehan, W. Marston, Bratslavsky, Gennady, Mollapour, Mehdi
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370319/
https://ncbi.nlm.nih.gov/pubmed/30699359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.018
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