Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity

The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is limited by lack of biomarkers to optimize patient se...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Woodford, Mark R., Hughes, Michael, Sager, Rebecca A., Backe, Sarah J., Baker-Williams, Alexander J., Bratslavsky, Michael S., Jacob, Joseph M., Shapiro, Oleg, Wong, Michael, Bratslavsky, Gennady, Bourboulia, Dimitra, Mollapour, Mehdi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791385/
https://ncbi.nlm.nih.gov/pubmed/31645902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27217
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