Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor

[Image: see text] DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. We have developed a fluorescence linked enzyme chemoproteomic strategy (FLECS) for the rapid ident...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Carlson, David A., Franke, Aaron S., Weitzel, Douglas H., Speer, Brittany L., Hughes, Philip F., Hagerty, Laura, Fortner, Christopher N., Veal, James M., Barta, Thomas E., Zieba, Bartosz J., Somlyo, Avril V., Sutherland, Cindy, Deng, Jing Ti, Walsh, Michael P., MacDonald, Justin A., Haystead, Timothy A. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445880/
https://ncbi.nlm.nih.gov/pubmed/24070067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400407c
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