Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF(α) inhibition for cancer and autoimmune disease

Tumor necrosis factor α (TNFα) has both positive and negative roles in human disease. In certain cancers, TNFα is infused locally to promote tumor regression, but dose-limiting inflammatory effects limit broader utility. In autoimmune disease, anti-TNFα antibodies control inflammation in most patien...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Totzke, Juliane, Gurbani, Deepak, Raphemot, Rene, Hughes, Philip F., Bodoor, Khaldon, Carlson, David A., Loiselle, David R., Bera, Asim K., Eibschutz, Liesl S., Perkins, Marisha M., Eubanks, Amber L., Campbell, Phillip L., Fox, David A., Westover, Kenneth D., Haystead, Timothy A. J., Derbyshire, Emily R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576570/
https://ncbi.nlm.nih.gov/pubmed/28820959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.07.011
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