Simultaneous reprogramming and gene editing of human fibroblasts

Por Howden, Sara E, Thomson, James A, Little, Melissa H
Publicado no Nat Protoc (2018)

Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9

Por Foltz, Leah P., Howden, Sara E., Thomson, James A., Clegg, Dennis O.
Publicado no Int J Mol Sci (2018)

Reporter‐based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

Por Howden, Sara E, Vanslambrouck, Jessica M, Wilson, Sean B, Tan, Ker Sin, Little, Melissa H
Publicado no EMBO Rep (2019)

Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts

Por Howden, Sara E., Maufort, John P., Duffin, Bret M., Elefanty, Andrew G., Stanley, Edouard G., Thomson, James A.
Publicado no Stem Cell Reports (2015)

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

Por Hou, Zhonggang, Zhang, Yan, Propson, Nicholas E., Howden, Sara E., Chu, Li-Fang, Sontheimer, Erik J., Thomson, James A.
Publicado em 2013

Phosphorylation regulates human OCT4

Por Brumbaugh, Justin, Hou, Zhonggang, Russell, Jason D., Howden, Sara E., Yu, Pengzhi, Ledvina, Aaron R., Coon, Joshua J., Thomson, James A.
Publicado em 2012

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

Por Howden, Sara E., McColl, Bradley, Glaser, Astrid, Vadolas, Jim, Petrou, Steven, Little, Melissa H., Elefanty, Andrew G., Stanley, Edouard G.
Publicado no Stem Cell Reports (2016)

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts

Por Vermilyea, Scott C., Guthrie, Scott, Meyer, Michael, Smuga-Otto, Kim, Braun, Katarina, Howden, Sara, Thomson, James A., Zhang, Su-Chun, Emborg, Marina E., Golos, Thaddeus G.
Publicado no Stem Cells Dev (2017)

Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment

Por Meyer, Jason S., Howden, Sara E., Wallace, Kyle A., Verhoeven, Amelia D., Wright, Lynda S., Capowski, Elizabeth E., Pinilla, Isabel, Martin, Jessica M., Tian, Shulan, Stewart, Ron, Pattnaik, Bikash, Thomson, James, Gamm, David M.
Publicado em 2011

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

Por Hale, Lorna J., Howden, Sara E., Phipson, Belinda, Lonsdale, Andrew, Er, Pei X., Ghobrial, Irene, Hosawi, Salman, Wilson, Sean, Lawlor, Kynan T., Khan, Shahnaz, Oshlack, Alicia, Quinlan, Catherine, Lennon, Rachel, Little, Melissa H.
Publicado no Nat Commun (2018)

Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1

Por Vanslambrouck, Jessica M., Woodard, Lauren E., Suhaimi, Norseha, Williams, Felisha M., Howden, Sara E., Wilson, Sean, Lonsdale, Andrew, Er, Pei X., Li, Joan, Maksimovic, Jovana, Oshlack, Alicia, Wilson, Matthew H., Little, Melissa H.
Publicado no Kidney Int (2019)

Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation

Por Capowski, Elizabeth E., Simonett, Joseph M., Clark, Eric M., Wright, Lynda S., Howden, Sara E., Wallace, Kyle A., Petelinsek, Anna M., Pinilla, Isabel, Phillips, M. Joseph, Meyer, Jason S., Schneider, Bernard L., Thomson, James A., Gamm, David M.
Publicado no Hum Mol Genet (2014)

A novel approach to single cell RNA-seq analysis facilitates in silico gene reporting of human pluripotent stem cell-derived retinal cell types

Por Phillips, M. Joseph, Jiang, Peng, Howden, Sara, Barney, Patrick, Min, Jee, York, Nathaniel W., Chu, Li-Fang, Capowski, Elizabeth E., Cash, Abigail, Jain, Shivani, Barlow, Katherine, Tabassum, Tasnia, Stewart, Ron, Pattnaik, Bikash R., Thomson, James A., Gamm, David M.
Publicado no Stem Cells (2017)

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

Por Forbes, Thomas A., Howden, Sara E., Lawlor, Kynan, Phipson, Belinda, Maksimovic, Jovana, Hale, Lorna, Wilson, Sean, Quinlan, Catherine, Ho, Gladys, Holman, Katherine, Bennetts, Bruce, Crawford, Joanna, Trnka, Peter, Oshlack, Alicia, Patel, Chirag, Mallett, Andrew, Simons, Cas, Little, Melissa H.
Publicado no Am J Hum Genet (2018)

Chemically defined conditions for human iPS cell derivation and culture

Por Chen, Guokai, Gulbranson, Daniel R., Hou, Zhonggang, Bolin, Jennifer M., Ruotti, Victor, Probasco, Mitchell D., Smuga-Otto, Kimberly, Howden, Sara E., Diol, Nicole R., Propson, Nicholas E., Wagner, Ryan, Lee, Garrett O., Antosiewicz-Bourget, Jessica, Teng, Joyce M. C., Thomson, James A.
Publicado em 2011

Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy

Por Howden, Sara E., Gore, Athurva, Li, Zhe, Fung, Ho-Lim, Nisler, Benjamin S., Nie, Jeff, Chen, Goukai, McIntosh, Brian E., Gulbranson, Daniel R., Diol, Nicole R., Taapken, Seth M., Vereide, David T., Montgomery, Karen Dyer, Zhang, Kun, Gamm, David M., Thomson, James A.
Publicado em 2011

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

Por van den Berg, Cathelijne W., Ritsma, Laila, Avramut, M. Cristina, Wiersma, Loes E., van den Berg, Bernard M., Leuning, Daniëlle G., Lievers, Ellen, Koning, Marije, Vanslambrouck, Jessica M., Koster, Abraham J., Howden, Sara E., Takasato, Minoru, Little, Melissa H., Rabelink, Ton J.
Publicado no Stem Cell Reports (2018)

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines

Por Capowski, Elizabeth E., Samimi, Kayvan, Mayerl, Steven J., Phillips, M. Joseph, Pinilla, Isabel, Howden, Sara E., Saha, Jishnu, Jansen, Alex D., Edwards, Kimberly L., Jager, Lindsey D., Barlow, Katherine, Valiauga, Rasa, Erlichman, Zachary, Hagstrom, Anna, Sinha, Divya, Sluch, Valentin M., Chamling, Xitiz, Zack, Donald J., Skala, Melissa C., Gamm, David M.
Publicado no Development (2019)

GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives

Por Kao, Tim, Labonne, Tanya, Niclis, Jonathan C., Chaurasia, Ritu, Lokmic, Zerina, Qian, Elizabeth, Bruveris, Freya F., Howden, Sara E., Motazedian, Ali, Schiesser, Jacqueline V., Costa, Magdaline, Sourris, Koula, Ng, Elizabeth, Anderson, David, Giudice, Antonietta, Farlie, Peter, Cheung, Michael, Lamande, Shireen R., Penington, Anthony J., Parish, Clare L., Thomson, Lachlan H., Rafii, Arash, Elliott, David A., Elefanty, Andrew G., Stanley, Edouard G.
Publicado no Stem Cell Reports (2016)