Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer

Por Houghton, A. McGarry
Publicado no Ann Am Thorac Soc (2018)

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

Por Gregory, Alyssa D., Hale, Pamela, Perlmutter, David H., Houghton, A. McGarry
Publicado em 2012

Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury

Por Kaynar, A. Murat, Houghton, A. McGarry, Lum, Esther H., Pitt, Bruce R., Shapiro, Steven D.
Publicado em 2008

Macrophage elastase kills bacteria within murine macrophages

Por Houghton, A. McGarry, Hartzell, William O., Robbins, Clinton S., Gomis-Rüth, F. Xavier, Shapiro, Steven D.
Publicado em 2009

Neutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in Mice

Por Shapiro, Steven D., Goldstein, Nir M., Houghton, A. McGarry, Kobayashi, Dale K., Kelley, Diane, Belaaouaj, Abderazzaq
Publicado em 2003

Lung Cancer Subtypes Generate Unique Immune Responses

Por Busch, Stephanie E., Hanke, Mark L., Kargl, Julia, Metz, Heather E., MacPherson, David, Houghton, A. McGarry
Publicado no J Immunol (2016)

Epithelial Cell Apoptosis Causes Acute Lung Injury Masquerading as Emphysema

Por Mouded, Majd, Egea, Eduardo E., Brown, Matthew J., Hanlon, Shane M., Houghton, A. McGarry, Tsai, Larry W., Ingenito, Edward P., Shapiro, Steven D.
Publicado em 2009

Endogenous CD4(+) T cells recognize neoantigens in lung cancer patients, including recurrent oncogenic KRAS and ERBB2 (Her2) driver mutations

Por Veatch, Joshua R., Jesernig, Brenda L., Kargl, Julia, Fitzgibbon, Matthew, Lee, Sylvia M., Baik, Christina, Martins, Renato, Houghton, A. McGarry, Riddell, Stanley R.
Publicado no Cancer Immunol Res (2019)

Elastin fragments drive disease progression in a murine model of emphysema

Por Houghton, A. McGarry, Quintero, Pablo A., Perkins, David L., Kobayashi, Dale K., Kelley, Diane G., Marconcini, Luiz A., Mecham, Robert P., Senior, Robert M., Shapiro, Steven D.
Publicado em 2006

Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis

Por Manicone, Anne M., Gharib, Sina A., Gong, Ke-Qin, Eddy, William E., Long, Matthew E., Frevert, Charles W., Altemeier, William A., Parks, William C., Houghton, A. McGarry
Publicado no Am J Pathol (2017)

Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

Por Gregory, Alyssa D., Kliment, Corrine R., Metz, Heather E., Kim, Kyoung-Hee, Kargl, Julia, Agostini, Brittani A., Crum, Lauren T., Oczypok, Elizabeth A., Oury, Tim A., Houghton, A. McGarry
Publicado no J Leukoc Biol (2015)

Mutant IDH1 regulates the tumor-associated immune system in gliomas

Por Amankulor, Nduka M., Kim, Youngmi, Arora, Sonali, Kargl, Julia, Szulzewsky, Frank, Hanke, Mark, Margineantu, Daciana H., Rao, Aparna, Bolouri, Hamid, Delrow, Jeff, Hockenbery, David, Houghton, A. McGarry, Holland, Eric C.
Publicado no Genes Dev (2017)

Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non–Small Cell Lung Cancer

Por Mark, Nicholas M., Kargl, Julia, Busch, Stephanie E., Yang, Grace H. Y., Metz, Heather E., Zhang, Huajia, Hubbard, Jesse J., Pipavath, Sudhakar N. J., Madtes, David K., Houghton, A. McGarry
Publicado no Am J Respir Crit Care Med (2018)

IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

Por Chen, Kong, Pociask, Derek A., McAleer, Jeremy P., Chan, Yvonne R., Alcorn, John F., Kreindler, James L., Keyser, Matthew R., Shapiro, Steven D., Houghton, A. McGarry, Kolls, Jay K., Zheng, Mingquan
Publicado em 2011

Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma

Por Metz, Heather E., Kargl, Julia, Busch, Stephanie E., Kim, Kyoung-Hee, Kurland, Brenda F., Abberbock, Shira R., Randolph-Habecker, Julie, Knoblaugh, Sue E., Kolls, Jay K., White, Morris F., Houghton, A. McGarry
Publicado no Proc Natl Acad Sci U S A (2016)

Neutrophils dominate the immune cell composition in non-small cell lung cancer

Por Kargl, Julia, Busch, Stephanie E., Yang, Grace H. Y., Kim, Kyoung-Hee, Hanke, Mark L., Metz, Heather E., Hubbard, Jesse J., Lee, Sylvia M., Madtes, David K., McIntosh, Martin W., Houghton, A. McGarry
Publicado no Nat Commun (2017)

TMIC-05. ABSCOPAL IMMUNE RESPONSE IN GLIOBLASTOMA ELICITED BY MIR124-ATTENUATED ONCOLYTIC HERPES SIMPLEX VIRUS 1 ARMED WITH UL16 BINDING PROTEIN 3

Por Wirsching, Hans-Georg, Zhang, Huajia, Grandi, Paola, Arora, Sonali, Cimino, Patrick J, Campbell, Jean S, Szulzewsky, Frank, Pattwell, Siobhan S, Ene, Chibawanye, Kumasaka, Debrah, Pierce, Robert H, Finer, Mitchell, Queva, Christophe, Houghton, A McGarry, Holland, Eric
Publicado no Neuro Oncol (2018)

Tumor-infiltrating BRAF(V600E)-specific CD4(+) T cells correlated with complete clinical response in melanoma

Por Veatch, Joshua R., Lee, Sylvia M., Fitzgibbon, Matthew, Chow, I-Ting, Jesernig, Brenda, Schmitt, Tom, Kong, Ying Ying, Kargl, Julia, Houghton, A. McGarry, Thompson, John A., McIntosh, Martin, Kwok, William W., Riddell, Stanley R.
Publicado no J Clin Invest (2018)

Tumor-derived Autoantibodies Identify Malignant Pulmonary Nodules

Por Lastwika, Kristin J., Kargl, Julia, Zhang, Yuzheng, Zhu, Xiaodong, Lo, Edward, Shelley, David, Ladd, Jon J., Wu, Wei, Kinahan, Paul, Pipavath, Sudhakar N. J., Randolph, Timothy W., Shipley, Melissa, Lampe, Paul D., Houghton, A. McGarry
Publicado no Am J Respir Crit Care Med (2019)

Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth

Por Houghton, A. McGarry, Rzymkiewicz, Danuta M., Ji, Hongbin, Gregory, Alyssa D., Egea, Eduardo E., Metz, Heather E., Stolz, Donna B., Land, Stephanie R., Marconcini, Luiz A., Kliment, Corrine R., Jenkins, Kimberly M., Beaulieu, Keith A., Mouded, Majd, Frank, Stuart J., Wong, Kwok K., Shapiro, Steven D.
Publicado em 2010