Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma

Insulin receptor substrate-1 (IRS-1) is a signaling adaptor protein that interfaces with many pathways activated in lung cancer. It has been assumed that IRS-1 promotes tumor growth through its ability to activate PI3K signaling downstream of the insulin-like growth factor receptor. Surprisingly, tu...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Metz, Heather E., Kargl, Julia, Busch, Stephanie E., Kim, Kyoung-Hee, Kurland, Brenda F., Abberbock, Shira R., Randolph-Habecker, Julie, Knoblaugh, Sue E., Kolls, Jay K., White, Morris F., Houghton, A. McGarry
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978299/
https://ncbi.nlm.nih.gov/pubmed/27439864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601989113
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