Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs has been negatively correlated with outcomes, the role played by neutrophils in lung fibrosis remains poorly understood. We have demonstra...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Gregory, Alyssa D., Kliment, Corrine R., Metz, Heather E., Kim, Kyoung-Hee, Kargl, Julia, Agostini, Brittani A., Crum, Lauren T., Oczypok, Elizabeth A., Oury, Tim A., Houghton, A. McGarry
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2015
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763951/
https://ncbi.nlm.nih.gov/pubmed/25743626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3HI1014-493R
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