Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs has been negatively correlated with outcomes, the role played by neutrophils in lung fibrosis remains poorly understood. We have demonstra...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Gregory, Alyssa D., Kliment, Corrine R., Metz, Heather E., Kim, Kyoung-Hee, Kargl, Julia, Agostini, Brittani A., Crum, Lauren T., Oczypok, Elizabeth A., Oury, Tim A., Houghton, A. McGarry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2015
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Spotlight on Leading Edge Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763951/
https://ncbi.nlm.nih.gov/pubmed/25743626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3HI1014-493R
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