Pharmacogenomics of Anti-platelet and Anti-coagulation Therapy

Por Fisch, Adam S., Perry, Christina G., Stephens, Sarah H., Horenstein, Richard B., Shuldiner, Alan R.
Publicado em 2013

A systematic analysis and comparison of warfarin initiation strategies

Por French, Benjamin, Wang, Le, Gage, Brian F., Horenstein, Richard B., Limdi, Nita A., Kimmel, Stephen E.
Publicado no Pharmacogenet Genomics (2016)

A Sensitive and Rapid Ultra HPLC-MS/MS Method for the Simultaneous Detection of Clopidogrel and its Derivatized Active Thiol Metabolite in Human Plasma

Por Peer, Cody J., Spencer, Shawn D., VanDenBerg, Dustin A. H., Pacanowski, Michael A., Horenstein, Richard B., Figg, William D.
Publicado em 2011

The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish

Por Horenstein, Richard B., Mitchell, Braxton D., Post, Wendy S., Lütjohann, Dieter, von Bergmann, Klaus, Ryan, Kathleen A., Terrin, Michael, Shuldiner, Alan R., Steinle, Nanette I.
Publicado em 2012

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers

Por Horenstein, Richard B., Madabushi, Rajnikanth, Zineh, Issam, Yerges-Armstrong, Laura M., Peer, Cody J., Schuck, Robert N., Figg, William Douglas, Shuldiner, Alan R., Pacanowski, Michael
Publicado em 2014

Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response i...

Por Jiang, Xi-Ling, Samant, Snehal, Lewis, Joshua P., Horenstein, Richard B., Shuldiner, Alan R., Yerges-Armstrong, Laura M., Peletier, Lambertus A., Lesko, Lawrence J., Schmidt, Stephan
Publicado no Eur J Pharm Sci (2015)

Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk

Por Bielak, Lawrence F., Horenstein, Richard B., Ryan, Kathleen A., Sheedy, Patrick F., Rumberger, John A., Tanner, Keith, Post, Wendy, Mitchell, Braxton D., Shuldiner, Alan R., Peyser, Patricia A.
Publicado em 2009

The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin

Por Bozzi, Laura M., Mitchell, Braxton D., Lewis, Joshua P., Ryan, Kathy A., Herzog, William R., O’Connell, Jeffrey R., Horenstein, Richard B., Shuldiner, Alan R., Yerges-Armstrong, Laura M.
Publicado no Curr Vasc Pharmacol (2016)

Pharmacogenetic associations of β1-adrenergic receptor polymorphisms with cardiovascular outcomes in the SPS3 trial

Por Magvanjav, Oyunbileg, McDonough, Caitrin W., Gong, Yan, McClure, Leslie A., Talbert, Robert L., Horenstein, Richard B., Shuldiner, Alan R., Benavente, Oscar R., Mitchell, Braxton D., Johnson, Julie A.
Publicado no Stroke (2017)

Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed-Pharmacogenomics

Por Yerges-Armstrong, Laura M., Ellero-Simatos, Sandrine, Georgiades, Anastasia, Zhu, Hongjie, Lewis, Joshua, Horenstein, Richard B., Beitelshees, Amber L., Dane, Adrie, Reijmers, Theo, Hankemeier, Thomas, Fiehn, Oliver, Shuldiner, Alan R., Kaddurah-Daouk, Rima
Publicado em 2013

CYP2C19 Metabolizer Status and Clopidogrel Efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) Study

Por McDonough, Caitrin W, McClure, Leslie A, Mitchell, Braxton D, Gong, Yan, Horenstein, Richard B, Lewis, Joshua P, Field, Thalia S, Talbert, Robert L, Benavente, Oscar R, Johnson, Julie A, Shuldiner, Alan R
Publicado no J Am Heart Assoc (2015)

Genome-Wide Analysis of Clopidogrel Active Metabolite Levels Identifies Novel Variants that Influence Antiplatelet Response

Por Backman, Joshua D., O’Connell, Jeffrey R., Tanner, Keith, Peer, Cody J., Figg, William D., Spencer, Shawn D., Mitchell, Braxton D., Shuldiner., Alan R., Yerges-Armstrong, Laura M., Horenstein, Richard B., Lewis, Joshua P.
Publicado no Pharmacogenet Genomics (2017)

Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications

Por Yang, Rong-Ze, Lee, Mi-Jeong, Hu, Hong, Pollin, Toni I, Ryan, Alice S, Nicklas, Barbara J, Snitker, Soren, Horenstein, Richard B, Hull, Kristen, Goldberg, Nelson H, Goldberg, Andrew P, Shuldiner, Alan R, Fried, Susan K, Gong, Da-Wei
Publicado em 2006

A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection

Por Pollin, Toni I., Damcott, Coleen M., Shen, Haiqing, Ott, Sandra H., Shelton, John, Horenstein, Richard B., Post, Wendy, McLenithan, John C., Bielak, Lawrence F., Peyser, Patricia A., Mitchell, Braxton D., Miller, Michael, O'Connell, Jeffrey R., Shuldiner, Alan R.
Publicado em 2008

Oxylipid Profile of Low‐Dose Aspirin Exposure: A Pharmacometabolomics Study

Por Ellero‐Simatos, Sandrine, Beitelshees, Amber L., Lewis, Joshua P., Yerges‐Armstrong, Laura M., Georgiades, Anastasia, Dane, Adrie, Harms, Amy C., Strassburg, Katrin, Guled, Faisa, Hendriks, Margriet M. W. B., Horenstein, Richard B., Shuldiner, Alan R., Hankemeier, Thomas, Kaddurah‐Daouk, Rima
Publicado no J Am Heart Assoc (2015)

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

Por Shuldiner, Alan R., O'Connell, Jeffrey R., Bliden, Kevin P., Gandhi, Amish, Ryan, Kathleen, Horenstein, Richard B., Damcott, Coleen M., Pakyz, Ruth, Tantry, Udaya S., Gibson, Quince, Pollin, Toni I., Post, Wendy, Parsa, Afshin, Mitchell, Braxton D., Faraday, Nauder, Herzog, William, Gurbel, Paul A.
Publicado em 2009

Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome

Por Zupancic, Margaret L., Cantarel, Brandi L., Liu, Zhenqiu, Drabek, Elliott F., Ryan, Kathleen A., Cirimotich, Shana, Jones, Cheron, Knight, Rob, Walters, William A., Knights, Daniel, Mongodin, Emmanuel F., Horenstein, Richard B., Mitchell, Braxton D., Steinle, Nanette, Snitker, Soren, Shuldiner, Alan R., Fraser, Claire M.
Publicado em 2012

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response

Por Lewis, Joshua P., Horenstein, Richard B., Ryan, Kathleen, O’Connell, Jeffrey R., Gibson, Quince, Mitchell, Braxton D., Tanner, Keith, Chai, Sumbul, Bliden, Kevin P., Tantry, Udaya S., Peer, Cody J., Figg, William D., Spencer, Shawn D., Pacanowski, Michael A., Gurbel, Paul A., Shuldiner, Alan R.
Publicado em 2013

Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

Por Albert, Jessica S., Yerges-Armstrong, Laura M., Horenstein, Richard B., Pollin, Toni I., Sreenivasan, Urmila T., Chai, Sumbul, Blaner, William S., Snitker, Soren, O'Connell, Jeffrey R., Gong, Da-Wei, Breyer, Richard J., Ryan, Alice S., McLenithan, John C., Shuldiner, Alan R., Sztalryd, Carole, Damcott, Coleen M.
Publicado em 2014

Familial Defective Apolipoprotein B-100 and Increased Low-Density Lipoprotein Cholesterol and Coronary Artery Calcification in the Old Order Amish

Por Shen, Haiqing, Damcott, Coleen M., Rampersaud, Evadnie, Pollin, Toni I., Horenstein, Richard B., McArdle, Patrick F., Peyser, Patricia A., Bielak, Lawrence F., Post, Wendy S., Chang, Yen-Pei C., Ryan, Kathleen A., Miller, Michael, Rumberger, John A., Sheedy, Patrick F., Shelton, John, O’Connell, Jeffrey R., Shuldiner, Alan R., Mitchell, Braxton D.
Publicado em 2010