Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

CONTEXT: Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous coronary intervention by inhibiting adenosine diphosphate (ADP)–dependent platelet activation. However, nonresponsiveness is widely recognized and is related to recurren...

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Hauptverfasser: Shuldiner, Alan R., O'Connell, Jeffrey R., Bliden, Kevin P., Gandhi, Amish, Ryan, Kathleen, Horenstein, Richard B., Damcott, Coleen M., Pakyz, Ruth, Tantry, Udaya S., Gibson, Quince, Pollin, Toni I., Post, Wendy, Parsa, Afshin, Mitchell, Braxton D., Faraday, Nauder, Herzog, William, Gurbel, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641569/
https://ncbi.nlm.nih.gov/pubmed/19706858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2009.1232
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