Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype Selective Ligands

di Sahn, James J., Hodges, Timothy R., Chan, Jessica Z., Martin, Stephen F.
Pubblicato in ChemMedChem (2016)

Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity

di Sahn, James J., Hodges, Timothy R., Chan, Jessica Z., Martin, Stephen F.
Pubblicato in ACS Med Chem Lett (2017)

High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model

di Monda, Sudip, Hegarty, Evan, Sahn, James J., Scott, Luisa L., Gökçe, Sertan Kutal, Martin, Chris, Ghorashian, Navid, Satarasinghe, Praveen Navoda, Iyer, Sangeetha, Sae-Lee, Wisath, Hodges, Timothy R., Pierce, Jonathan T., Martin, Stephen F., Ben-Yakar, Adela
Pubblicato in ACS Chem Neurosci (2018)

Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

di Scott, Luisa L., Sahn, James J., Ferragud, Antonio, Yen, Rachel C., Satarasinghe, Praveen N., Wood, Michael D., Hodges, Timothy R., Shi, Ted, Prakash, Brooke A., Friese, Kaitlyn M., Shen, Angela, Sabino, Valentina, Pierce, Jonathan T., Martin, Stephen F.
Pubblicato in Neuropsychopharmacology (2018)

Neuroprotective Efficacy of a Sigma 2 Receptor/TMEM97 Modulator (DKR-1677) after Traumatic Brain Injury

di Vázquez-Rosa, Edwin, Watson, Michael R., Sahn, James J., Hodges, Timothy R., Schroeder, Rachel E., Cintrón-Pérez, Coral J., Shin, Min-Kyoo, Yin, Terry C., Emery, Josie L., Martin, Stephen F., Liebl, Daniel J., Pieper, Andrew A.
Pubblicato in ACS Chem Neurosci (2018)

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

di Hodges, Timothy R., Abbott, Jason R., Little, Andrew J., Sarkar, Dhruba, Salovich, James M., Howes, Jennifer E., Akan, Denis T., Sai, Jiqing, Arnold, Allison L., Browning, Carrie, Burns, Michael C., Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A., Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W., Phan, Jason, Waterson, Alex G., McConnell, Darryl B., Fesik, Stephen W.
Pubblicato in J Med Chem (2018)