Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons

Por Matsuda, Shinji, Launey, Thomas, Mikawa, Sumiko, Hirai, Hirokazu
Publicado em 2000

Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre–Purkinje cell synapses in staggerer mutant mice

Por Mitsumura, Kazuhiro, Hosoi, Nobutake, Furuya, Nobuhiko, Hirai, Hirokazu
Publicado em 2011

Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

Por Irie, Tomohiko, Matsuzaki, Yasunori, Sekino, Yuko, Hirai, Hirokazu
Publicado em 2014

Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia

Por Sawada, Yusuke, Konno, Ayumu, Nagaoka, Jun, Hirai, Hirokazu
Publicado no Sci Rep (2016)

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice

Por Shuvaev, Anton N., Hosoi, Nobutake, Sato, Yamato, Yanagihara, Dai, Hirai, Hirokazu
Publicado no J Physiol (2016)

The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice

Por Oue, Miho, Handa, Hiroshi, Matsuzaki, Yasunori, Suzue, Kazutomo, Murakami, Hirokazu, Hirai, Hirokazu
Publicado em 2012

Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

Por Shinohara, Yoichiro, Konno, Ayumu, Takahashi, Nobutaka, Matsuzaki, Yasunori, Kishi, Shoji, Hirai, Hirokazu
Publicado no PLoS One (2016)

Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes

Por Hirai, Hirokazu, Miyazaki, Taisuke, Kakegawa, Wataru, Matsuda, Shinji, Mishina, Masayoshi, Watanabe, Masahiko, Yuzaki, Michisuke
Publicado em 2005

Ca(2+) permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination

Por Kakegawa, Wataru, Miyazaki, Taisuke, Hirai, Hirokazu, Motohashi, Junko, Mishina, Masayoshi, Watanabe, Masahiko, Yuzaki, Michisuke
Publicado em 2007

Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum

Por Mikuni, Takayasu, Uesaka, Naofumi, Okuno, Hiroyuki, Hirai, Hirokazu, Deisseroth, Karl, Bito, Haruhiko, Kano, Masanobu
Publicado em 2013

Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

Por Huda, Fathul, Konno, Ayumu, Matsuzaki, Yasunori, Goenawan, Hanna, Miyake, Koichi, Shimada, Takashi, Hirai, Hirokazu
Publicado no Mol Ther Methods Clin Dev (2014)

Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue

Por Okonogi, Noriyuki, Nakamura, Kazuhiro, Suzuki, Yoshiyuki, Suto, Nana, Suzue, Kazutomo, Kaminuma, Takuya, Nakano, Takashi, Hirai, Hirokazu
Publicado em 2014

Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

Por Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Hirai, Hirokazu, Déglon, Nicole, de Almeida, Luís Pereira
Publicado em 2013

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia

Por Torashima, Takashi, Koyama, Chiho, Iizuka, Akira, Mitsumura, Kazuhiro, Takayama, Kiyohiko, Yanagi, Shigeru, Oue, Miho, Yamaguchi, Haruyasu, Hirai, Hirokazu
Publicado em 2008

A Large Form of Secretogranin III Functions as a Sorting Receptor for Chromogranin A Aggregates in PC12 Cells

Por Han, Lu, Suda, Masayuki, Tsuzuki, Keisuke, Wang, Rong, Ohe, Yoshihide, Hirai, Hirokazu, Watanabe, Tsuyoshi, Takeuchi, Toshiyuki, Hosaka, Masahiro
Publicado em 2008

Fusion of Human Fetal Mesenchymal Stem Cells with “Degenerating” Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice

Por Huda, Fathul, Fan, Yiping, Suzuki, Mamiko, Konno, Ayumu, Matsuzaki, Yasunori, Takahashi, Nobutaka, Chan, Jerry K. Y., Hirai, Hirokazu
Publicado no PLoS One (2016)

A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein

Por Qin, Qingyu, Inatome, Ryoko, Hotta, Azusa, Kojima, Masaki, Yamamura, Hirohei, Hirai, Hirokazu, Yoshizawa, Toshihiro, Tanaka, Hirofumi, Fukami, Kiyoko, Yanagi, Shigeru
Publicado em 2006

FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype

Por Arsenault, Jason, Gholizadeh, Shervin, Niibori, Yosuke, Pacey, Laura K., Halder, Sebok K., Koxhioni, Enea, Konno, Ayumu, Hirai, Hirokazu, Hampson, David R.
Publicado no Hum Gene Ther (2016)

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

Por Monai, Hiromu, Ohkura, Masamichi, Tanaka, Mika, Oe, Yuki, Konno, Ayumu, Hirai, Hirokazu, Mikoshiba, Katsuhiko, Itohara, Shigeyoshi, Nakai, Junichi, Iwai, Youichi, Hirase, Hajime
Publicado no Nat Commun (2016)

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Por Conceição, Mariana, Mendonça, Liliana, Nóbrega, Clévio, Gomes, Célia, Costa, Pedro, Hirai, Hirokazu, Moreira, João Nuno, Lima, Maria C., Manjunath, N., de Almeida, Luís Pereira
Publicado no Data Brief (2016)