Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia

Polyglutamine disorders are inherited neurodegenerative diseases caused by the accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregates through the ubiquitin–proteasome pathway in cul...

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Detalhes bibliográficos
Main Authors: Torashima, Takashi, Koyama, Chiho, Iizuka, Akira, Mitsumura, Kazuhiro, Takayama, Kiyohiko, Yanagi, Shigeru, Oue, Miho, Yamaguchi, Haruyasu, Hirai, Hirokazu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288764/
https://ncbi.nlm.nih.gov/pubmed/18344973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.31
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