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Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell‐Conditioned Medium in Spinocerebellar Ataxia Type 1‐Knock‐in Mice

AIMS: Spinocerebellar ataxia type 1 (SCA1) is caused by the ataxin‐1 protein (ATXN1) with an abnormally expanded polyglutamine tract and is characterized by progressive neurodegeneration. We previously showed that intrathecal injection of mesenchymal stem cells (MSCs) during the nonsymptomatic stage...

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Опубликовано в: :CNS Neurosci Ther
Главные авторы: Suto, Nana, Mieda, Tokue, Iizuka, Akira, Nakamura, Kazuhiro, Hirai, Hirokazu
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492824/
https://ncbi.nlm.nih.gov/pubmed/27140210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12560
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