Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum

Neural circuits are shaped by activity-dependent elimination of redundant synapses during postnatal development. In many systems, postsynaptic activity is known to be crucial, but the precise mechanisms remain elusive. Here we report that the immediate early gene Arc/Arg3.1 mediates elimination of s...

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Huvudupphovsmän: Mikuni, Takayasu, Uesaka, Naofumi, Okuno, Hiroyuki, Hirai, Hirokazu, Deisseroth, Karl, Bito, Haruhiko, Kano, Masanobu
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773328/
https://ncbi.nlm.nih.gov/pubmed/23791196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.04.036
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