Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum

Neural circuits are shaped by activity-dependent elimination of redundant synapses during postnatal development. In many systems, postsynaptic activity is known to be crucial, but the precise mechanisms remain elusive. Here we report that the immediate early gene Arc/Arg3.1 mediates elimination of s...

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Main Authors: Mikuni, Takayasu, Uesaka, Naofumi, Okuno, Hiroyuki, Hirai, Hirokazu, Deisseroth, Karl, Bito, Haruhiko, Kano, Masanobu
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773328/
https://ncbi.nlm.nih.gov/pubmed/23791196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.04.036
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