Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

The neuronal immediate early gene Arc/Arg-3.1 is widely used as one of the most reliable molecular markers for intense synaptic activity in vivo. However, the cis-acting elements responsible for such stringent activity dependence have not been firmly identified. Here we combined luciferase reporter...

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Autors principals: Kawashima, Takashi, Okuno, Hiroyuki, Nonaka, Mio, Adachi-Morishima, Aki, Kyo, Nan, Okamura, Michiko, Takemoto-Kimura, Sayaka, Worley, Paul F., Bito, Haruhiko
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629236/
https://ncbi.nlm.nih.gov/pubmed/19116276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806518106
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